On November 29, 2023, at the invitation of Professor Zhao Qi of the University of Macau, Chief Scientist Professor Wang Jianxun gave a keynote speech entitled "Progress and Prospect of Immunotherapy for Cancer" for the Faculty and students of the Faculty of Health Sciences of the University of Macau. This paper introduces the latest advances and industrialization of cell and gene therapy for cancer.

First of all, Professor Wang introduced in detail the latest research progress of the team in the field of cell therapy. Professor Wang Jianxun's team designed a vector system targeting the co-expression of miR155 or LSD1 shRNA and anti-CD19 CAR. The system has two promoter elements to ensure the stable expression of regulatory genes and CAR. After the successful preparation of CAR-T cells, the anti-tumor function of CAR-T cells is uated in vitro and in vivo, with a view to enhancing the function of CAR-T cells through the regulation of epigenetic modification. The results showed that the co-expression of miR155 or LSD1 shRNA with CD19 can enhance the anti-tumor function of CD19 CAR-T cells in vitro and in vitro. The relevant work was published in the well-known journal Frontiers in Immunology. Cell therapy is widely regarded as the most promising clinical treatment, which has the potential to cure a variety of refractory diseases.

Then, Professor Wang introduced the development history, strategic objectives, core technology - industrial production of retroviral vector and its outstanding advantages in production capacity and cost. He said that Shenzhen Cell Valley, as the only CRO/CDMO enterprise with industrial production of retroviral vector in China, has cutting-edge technology and experienced R & D and production team, and is committed to solving the "stuck neck" pain points of cell and gene therapy. For enterprises, universities, research institutes, medical groups to provide from the early R & D pipeline to IND auxiliary declaration of the whole process services, at the same time, Shenzhen Cell Valley will in the process of cell therapy industrialization, continue to promote technological innovation and production quality control, through continuous optimization of the process, explore the innovation of cell therapy products, to ensure the safety and effectiveness of cell therapy products. Promote the wide application of cell products in the treatment of tumors.

Through this special lecture in the University of Macau, the communication of cutting-edge science and technology of cell and gene therapy has been established, and a solid foundation has been laid for promoting the progress of science and technology and technical talents in the field of cell therapy.